An improved disposition resulting in higher concentrations at the target site.
Advantages of the CriPec® platform:
CriPec®-oligonucleotides are CriPec®-based nanoparticles incorporating therapeutic oligonucleotides such as siRNA and antisense RNA, which are able to regulate the expression of genes.
CriPec®-oligonucleotides are designed to overcome the major shortcomings of current oligonucleotide therapies, including poor biodistribution, ineffective tissue targeting and inappropriate cellular processing, which result from endosomal uptake and subsequent lysosomal degradation. CriPec®-oligonucleotides aim to selectively and effectively target the correct subcellular compartment in the diseased tissue.