Customized, tuneable drug release
The linkers that temporarily entrap the drug within the CriPec® nanoparticle determine the site and rate of release of the native drug molecule i.e. hours – days.
Importantly, drug release can be customized and it is driven by (purely) chemically-induced cleavage.
Release profiles in both in vitro and in vivo are anticipated to closely match due to the absence of enzymes in the process. With CriPec®-DUO, 2 different APIs with completely dissimilar release profiles can be generated with the aim of producing synergistic therapeutic effects.