From discovery to delivery: CliCr‑enabled Cas9–siRNA conjugates for advanced gene editing

A recent publication by CliCr inventor Matt Timmers describes an engineered SpCas9 platform bearing azide handles, enabling site-specific CliCr conjugation of siRNA while preserving both Cas9 editing and siRNA silencing activity. By applying the same CliCr chemistry, researchers can also generate targeted Cas9–siRNA–loaded LNPs, demonstrating a route to highly programmable and optimized delivery of gene-editing therapies. Read the full publication here: https://pubs.rsc.org/en/content/articlelanding/2026/cc/d6cc01443g